For those not familiar with the taglines history: "Zo" stems from "Zo. Nu eerst een Bavaria." which comes from the insight that a beer tastes a lot better after you've done hard work to deserve it, thus: "Now, a Bavaria" as the answer to countless funny ads depicting people doing clever or not-so-hard-work to finally deserve the beer.
In Hugh Hefners case, he first need to keep all his lady friends happy all day. Nice work if you can get it.